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Journal article

Crystallization and preliminary X-ray diffraction characterisation of both a native and selenomethionyl VLA-4 binding fragment of VCAM-1.

Abstract:

Soluble fragments of the extracellular region of vascular cell adhesion molecule 1 (VCAM-1) expressed in Escherichia coli retain functional adhesive activity. An integrin (VLA-4) binding fragment consisting of the N-terminal two immunoglobulin-like domains (VCAM-d1,2) has been crystallized. The crystals belong to space group P2(1)2(1)2(1) with cell dimensions of a = 52.7 A, b = 66.5 A, c = 113.2 A and contain two molecules in the crystallographic asymmetric unit. A batch of protein produced i...

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Publication status:
Published

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Publisher copy:
10.1006/jmbi.1994.1743

Authors


Bottomley, MJ More by this author
Robinson, RC More by this author
Driscoll, PC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
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Journal:
Journal of molecular biology
Volume:
244
Issue:
4
Pages:
464-468
Publication date:
1994-12-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:d796986a-063f-4185-aa9f-b6aec2b6b399
Source identifiers:
23644
Local pid:
pubs:23644

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