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Journal article

Effect of etanercept concentration on human islet integrity

Abstract:

Etanercept is widely used as an antiinflammatory drug to improve engraftment after intraportal islet transplantation. In contrast to other immunosuppressive agents, very little is known about detrimental effects of etanercept on islets. The aim of this pilot study was to define the toxic range of etanercept.Human islets isolated from 8 donors were cultured for 4-5 days at 37°C in culture medium supplemented with etanercept at concentrations from 2.5 to 40 μg/mL, corresponding to potential in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0001-5117-4447
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Oxford college:
St Edmund Hall
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Transplantation Proceedings Journal website
Volume:
49
Issue:
10
Pages:
2327-2329
Publication date:
2017-12-01
DOI:
EISSN:
1873-2623
ISSN:
0041-1345
Pubs id:
pubs:811141
URN:
uri:d7955c58-338c-4193-83ee-7eb74f13d091
UUID:
uuid:d7955c58-338c-4193-83ee-7eb74f13d091
Local pid:
pubs:811141
Language:
English

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