- Abstract:
-
Etanercept is widely used as an antiinflammatory drug to improve engraftment after intraportal islet transplantation. In contrast to other immunosuppressive agents, very little is known about detrimental effects of etanercept on islets. The aim of this pilot study was to define the toxic range of etanercept.Human islets isolated from 8 donors were cultured for 4-5 days at 37°C in culture medium supplemented with etanercept at concentrations from 2.5 to 40 μg/mL, corresponding to potential in ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.transproceed.2017.11.002
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Transplantation Proceedings Journal website
- Volume:
- 49
- Issue:
- 10
- Pages:
- 2327-2329
- Publication date:
- 2017-12-01
- DOI:
- EISSN:
-
1873-2623
- ISSN:
-
0041-1345
- Pubs id:
-
pubs:811141
- URN:
-
uri:d7955c58-338c-4193-83ee-7eb74f13d091
- UUID:
-
uuid:d7955c58-338c-4193-83ee-7eb74f13d091
- Local pid:
- pubs:811141
- Language:
- English
- Copyright holder:
- Elsevier Inc.
- Copyright date:
- 2017
- Notes:
- © 2017 Elsevier Inc. All rights reserved.
Journal article
Effect of etanercept concentration on human islet integrity
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