JNK signalling in human and experimental renal ischaemia/reperfusion injury.

Journal article

BACKGROUND: Ischaemia/reperfusion (I/R) is an important factor in delayed graft function in renal transplantation and is a determinant of long-term graft outcome. This study examined the role of c-Jun N-terminal kinase (JNK) signalling in human and experimental renal I/R injury. METHODS: Biopsies obtained 15-20 min after reperfusion of human renal allografts were examined for JNK signalling by immunostaining for phospho-c-Jun. To examine the pathologic role of JNK signalling, a selective JNK...

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Authors: Kanellis, J; Ma, F; Kandane-Rathnayake, R; Dowling, J; Polkinghorne, K

• Publication status: Published
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
• Volume: 25
• Issue: 9
• Pages: 2898-2908
• Publication date: 2010-09-01
• DOI: 10.1093/ndt/gfq147
• EISSN: 1460-2385
• ISSN: 0931-0509
• Language: English
• Keywords: Humans; JNK Mitogen-Activated Protein Kinases; Pyrazolones; Animals; Signal Transduction; Acute Kidney Injury; Reverse Transcriptase Polymerase Chain Reaction; Rats; Male; Blotting, Western; Kidney Transplantation; Immunoenzyme Techniques; Rats, Sprague-Dawley; Inflammation Mediators; RNA, Messenger; Reperfusion Injury; Disease Models, Animal