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BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming

Abstract:

Epigenetic reprogramming to pluripotency requires extensive remodeling of chromatin landscapes to silence existing cell-type-specific genes and activate pluripotency genes. ATP-dependent chromatin remodeling complexes are important regulators of chromatin structure and gene expression; however, the role of recently identified Bromodomain-containing protein 9 (BRD9) and the associated non-canonical BRG1-associated factors (ncBAF) complex in reprogramming remains unknown. Here, we show that gen...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.stemcr.2022.10.005

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Publisher:
Cell Press
Journal:
Stem Cell Reports More from this journal
Volume:
17
Issue:
12
Pages:
2629-2642
Publication date:
2022-11-03
Acceptance date:
2022-10-06
DOI:
EISSN:
2213-6711
Pmid:
36332631
Language:
English
Keywords:
Pubs id:
1299842
Local pid:
pubs:1299842
Deposit date:
2023-01-09

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