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Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study.

Abstract:

Ketamine is a N-methyl-D-aspartic acid (NMDA) antagonist that has been associated with temporary clinical improvement in patients with depression. Studies using magnetic resonance spectroscopy (MRS) have shown that major depression is associated with decreased levels of glutamate and glutamine (Glx) in the anterior cingulate cortex, which normalize with clinical recovery. The present study aimed to test whether a ketamine infusion would increase cortical Glx levels in healthy volunteers. Heal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Files:
Publisher copy:
10.1177/0269881111405359

Authors


Taylor, MJ More by this author
Tiangga, ER More by this author
Mhuircheartaigh, RN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Medical Research Council More from this funder
Publisher:
SAGE Publisher's website
Volume:
26
Issue:
5
Pages:
733-737
Publication date:
2012-05-05
DOI:
EISSN:
1461-7285
ISSN:
0269-8811
URN:
uuid:d77f22e0-a9ff-4a14-bc95-266d669f601e
Source identifiers:
139662
Local pid:
pubs:139662

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