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XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

Abstract:

X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations inXIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAPor deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and re...

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Authors


Müller, N More by this author
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Publisher:
Elsevier
Journal:
Cell Reports
Volume:
7
Issue:
6
Pages:
1796-1808
Publication date:
2014-06-26
DOI:
EISSN:
2211-1247
URN:
uuid:d7720515-4fa2-4ff6-8248-4e31bf89b136
Source identifiers:
477379
Local pid:
pubs:477379
Language:
English

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