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A Sox10 enhancer element common to the otic placode and neural crest is activated by tissue-specific paralogs.

Abstract:

The otic placode, a specialized region of ectoderm, gives rise to components of the inner ear and shares many characteristics with the neural crest, including expression of the key transcription factor Sox10. Here, we show that in avian embryos, a highly conserved cranial neural crest enhancer, Sox10E2, also controls the onset of Sox10 expression in the otic placode. Interestingly, we show that different combinations of paralogous transcription factors (Sox8, Pea3 and cMyb versus Sox9, Ets1 a...

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Publisher copy:
10.1242/dev.057836

Authors


Betancur, P More by this author
Sauka-Spengler, T More by this author
Bronner, M More by this author
Journal:
Development (Cambridge, England)
Volume:
138
Issue:
17
Pages:
3689-3698
Publication date:
2011-09-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:d7639c76-68ce-4cbd-a634-3f288a2c7e19
Source identifiers:
257400
Local pid:
pubs:257400

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