Journal article icon

Journal article

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.

Abstract:

Environmental factors account for 75% of the risk of developing multiple sclerosis (MS). Numerous infections have been suspected as environmental disease triggers, but none of them has consistently been incriminated, and it is unclear how so many different infections may play a role. We show that a microbial peptide, common to several major classes of bacteria, can induce MS-like disease in humanized mice by crossreacting with a T cell receptor (TCR) that also recognizes a peptide from myelin...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Immunity
Volume:
30
Issue:
3
Pages:
348-357
Publication date:
2009-03-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:d75c8853-9b6c-4d8e-8c13-aa2a73ce3c3c
Source identifiers:
3872
Local pid:
pubs:3872

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP