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A century of enzyme kinetics. Should we believe in the Km and vmax estimates?

Abstract:

The application of the quasi-steady-state approximation (QSSA) in biochemical kinetics allows the reduction of a complex biochemical system with an initial fast transient into a simpler system. The simplified system yields insights into the behavior of the biochemical reaction, and analytical approximations can be obtained to determine its kinetic parameters. However, this process can lead to inaccuracies due to the inappropriate application of the QSSA. Here we present a number of approximat...

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Publication date:
2003-01-01
URN:
uuid:d75c660d-d149-4f8e-994d-bb5b5fc0cec1
Local pid:
oai:eprints.maths.ox.ac.uk:381

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