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GWAS in autoimmune thyroid disease: Redefining our understanding of pathogenesis

Abstract:

The ability of the immune system to protect the body from attack by foreign antigens is essential for human survival. The immune system can, however, start to attack the body's own organs. An autoimmune response against components of the thyroid gland affects 2-5% of the general population. Considerable familial clustering is also observed in autoimmune thyroid disease (AITD). Teasing out the genetic contribution to AITD over the past 40 years has helped unravel how immune disruption leads to...

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Publisher copy:
10.1038/nrendo.2013.56

Authors


Simmonds, MJ More by this author
Journal:
Nature Reviews Endocrinology
Volume:
9
Issue:
5
Pages:
277-287
Publication date:
2013-05-05
DOI:
EISSN:
1759-5037
ISSN:
1759-5029
URN:
uuid:d750d937-62b2-49b5-875f-1cd211cab207
Source identifiers:
400531
Local pid:
pubs:400531
Language:
English

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