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CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis.

Abstract:

We have developed a method to generate alloreactive regulatory T cells in vitro in the presence of interferon (IFN)-gamma and donor antigen presenting cells (APCs). We hypothesized that these IFN-gamma-conditioned T cells (Tcon) would reduce transplantation-associated arteriosclerosis. Tcon were generated from mouse (CBA.Ca, H-2(k)) CD4(+) T cells cultured in the presence of IFN-gamma for 14 days. These cultures were pulsed with bone marrow-derived B6 (H-2(b)) APC. 1 x 10(5) CD25(-)CD4(+) eff...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2010.090292

Authors


Warnecke, G More by this author
Francis, R More by this author
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Journal:
The American journal of pathology
Volume:
177
Issue:
1
Pages:
464-472
Publication date:
2010-07-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:d748ba47-9194-40e1-b997-a96a351d123c
Source identifiers:
135991
Local pid:
pubs:135991

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