- Abstract:
-
Most cancer genomes are characterized by the gain or loss of copies of some sequences through deletion, amplification or unbalanced translocations. Delineating and quantifying these changes is important in understanding the initiation and progression of cancer, in identifying novel therapeutic targets, and in the diagnosis and prognosis of individual patients. Conventional methods for measuring copy-number are limited in their ability to analyse large numbers of loci, in their dynamic range a...
Expand abstract - Publisher copy:
- 10.1002/path.2413
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- Journal:
- The Journal of pathology
- Volume:
- 216
- Issue:
- 3
- Pages:
- 307-316
- Publication date:
- 2008-11-05
- DOI:
- EISSN:
-
1096-9896
- ISSN:
-
0022-3417
- URN:
-
uuid:d7355a5a-6a2b-4af2-8bb4-ea32234f63f0
- Source identifiers:
-
324315
- Local pid:
- pubs:324315
- Copyright date:
- 2008
Journal article
Microdissection molecular copy-number counting (microMCC)--unlocking cancer archives with digital PCR.
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