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KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo.

Abstract:

BACKGROUND: Endothelial dysfunction contributes to ischemia-reperfusion injury (IRI) and is reduced by ischemic preconditioning (IPC). IPC may involve activation of ATP-sensitive potassium channels (K(ATP)). We determined whether modulation of K(ATP) channels occurs in endothelial IPC in humans. METHODS AND RESULTS: IRI of the forearm was induced by inflating a blood pressure cuff to 200 mm Hg for 20 minutes in healthy volunteers. K(ATP) activation was modulated by intra-arterial glibenclamid...

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Publication status:
Published

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Authors


Broadhead, MW More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Peters, MJ More by this author
MacAllister, RJ More by this author
Journal:
Circulation
Volume:
110
Issue:
15
Pages:
2077-2082
Publication date:
2004-10-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:d7328843-7b2b-4aa3-b194-6fdf6257a8fd
Source identifiers:
104936
Local pid:
pubs:104936

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