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Journal article

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.

Abstract:

Both the epidermal growth factor (EGF) and the vascular endothelial growth factor (VEGF) pathways are associated with intestinal cancer, and therapeutic approaches targeting either EGF receptor (EGFR) or VEGF receptor (VEGFR) signaling have recently been approved for patients with advanced colorectal cancer. The Apc(Min/+) mouse is a well-characterized in vivo model of intestinal tumorigenesis, and animals with this genetic mutation develop macroscopically detectable adenomas from approximate...

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Publication status:
Published

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Authors


Alferez, D More by this author
Wilkinson, RW More by this author
Watkins, J More by this author
Poulsom, R More by this author
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Journal:
Molecular cancer therapeutics
Volume:
7
Issue:
3
Pages:
590-598
Publication date:
2008-03-05
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
URN:
uuid:d72f81a6-0140-4a88-9fcc-cb681cf09806
Source identifiers:
312621
Local pid:
pubs:312621

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