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Haplotype-specific expression of the N-terminal exons 2 and 3 at the human MAPT locus.

Abstract:

The microtubule-associated protein tau (MAPT) H1 haplotype shows a strong association to the sporadic neurodegenerative diseases, progressive supranuclear palsy and corticobasal degeneration. The functional biological mechanisms behind the genetic association have started to emerge with differences recently shown in haplotype splicing of the neuropathologically relevant exon 10. Here we investigate the hypothesis that expression of the alternatively spliced N-terminal exons also differs betwe...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
Neurobiology of aging
Volume:
29
Issue:
12
Pages:
1923-1929
Publication date:
2008-12-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:d726c3f3-4da4-4ec4-9629-89318b5a32a5
Source identifiers:
113955
Local pid:
pubs:113955
Language:
English
Keywords:

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