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The effect of chronic antidepressant administration on beta-adrenoceptor function of the rat pineal.

Abstract:

1 The beta-adrenoceptor agonist, isoprenaline (1.5-3.0 mg kg(-1) intravenously), produced a dose-related increase in rat pineal melatonin content. This increase was prevented by pretreatment with the selective beta(1)-adrenoceptor antagonist, atenolol (2 mg kg(-1)), but not by the beta(2)-adrenoceptor antagonist, butoxamine (2 mg kg(-1)). The beta(2)-adrenoceptor agonist, terbutaline (5.0 mg kg(-1)), produced a moderate increase in pineal melatonin content.2 Repeated daily administration of d...

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Publication status:
Published

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Journal:
British journal of pharmacology
Volume:
78
Issue:
1
Pages:
89-96
Publication date:
1983-01-05
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
URN:
uuid:d71baa33-1873-40bf-b7ab-68f0520d603e
Source identifiers:
185959
Local pid:
pubs:185959

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