Journal article
Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.
- Abstract:
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INTRODUCTION: Despite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF)--a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that the majority of human genes undergo alternat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.8MB, Terms of use)
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- Publisher copy:
- 10.1186/ar2447
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Funding
Bibliographic Details
- Publisher:
- BioMed Central
- Journal:
- Arthritis research and therapy More from this journal
- Volume:
- 10
- Issue:
- 4
- Pages:
- R73
- Publication date:
- 2008-01-01
- DOI:
- EISSN:
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1478-6362
- ISSN:
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1478-6354
Item Description
- Language:
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English
- Keywords:
-
- UUID:
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uuid:d70faa7b-55b6-45aa-a30e-677719496f4f
- Local pid:
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pubs:223906
- Source identifiers:
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223906
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Jin et al
- Copyright date:
- 2008
- Notes:
- © 2008 Jin et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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