- Abstract:
-
The high-affinity receptor for immunoglobulin E (IgE), FcepsilonRI, is an alphabetagamma2 tetramer found on mast cells, basophils, and several other types of immune effector cells. The interaction of IgE with the alpha-subunit of FcepsilonRI is central to the pathogenesis of allergy. Detailed knowledge of the mode of interaction of FcepsilonRI with IgE may facilitate the development of inhibitors for general use in the treatment of allergic disease. To this end we have performed site-directed...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/bi9713005
-
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- Journal:
- Biochemistry
- Volume:
- 36
- Issue:
- 50
- Pages:
- 15579-15588
- Publication date:
- 1997-12-05
- DOI:
- EISSN:
-
1520-4995
- ISSN:
-
0006-2960
- URN:
-
uuid:d70b055e-58a7-4fa4-9bd2-a6c04c7502bc
- Source identifiers:
-
171619
- Local pid:
- pubs:171619
- Language:
- English
- Keywords:
- Copyright date:
- 1997
Journal article
Identification of contact residues in the IgE binding site of human FcepsilonRIalpha.
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