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Neuroanatomical targets of anxiogenic drugs in the hindbrain as revealed by Fos immunocytochemistry.

Abstract:

It is speculated that specific hindbrain transmitter pathways centred on the periaqueductal gray and locus coeruleus are an important integrative neural substrate for the expression of anxiety and the somatic symptoms and cardiovascular changes that accompany severe anxiety states, such as in panic disorder. Here we investigated the effects of various drugs, known to induce panic in humans and to be anxiogenic in animals, on Fos expression in the periaqueductal gray, locus coeruleus and other...

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Publication status:
Published

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Authors


Singewald, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Neuroscience
Volume:
98
Issue:
4
Pages:
759-770
Publication date:
2000
DOI:
EISSN:
1873-7544
ISSN:
0306-4522
URN:
uuid:d6ef371a-28e0-4dc9-9871-06c356e3a491
Source identifiers:
185334
Local pid:
pubs:185334

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