Journal article
IgA and IgG1 specific to vi polysaccharide of salmonella typhi correlate with protection status in a typhoid fever controlled human infection model
- Abstract:
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Vaccination against Salmonella Typhi using the Vi capsular polysaccharide, a T-cell independent antigen, can protect from the development of typhoid fever. This implies that antibodies to Vi alone can protect in the absence of a T cell-mediated immune response; however, protective Vi antibodies have not been well-characterized. We hypothesized that variability in the biophysical properties of vaccine-elicited antibodies, including subclass distribution and avidity, may impact protective outco...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.6MB, Terms of use)
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- Publisher copy:
- 10.3389/fimmu.2019.02582
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Bibliographic Details
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Immunology More from this journal
- Volume:
- 10
- Article number:
- 2582
- Publication date:
- 2019-11-01
- Acceptance date:
- 2019-10-17
- DOI:
- EISSN:
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1664-3224
- Pmid:
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31781100
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1075308
- UUID:
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uuid:d6ea66f8-cc02-4669-bc01-fda2b3577208
- Local pid:
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pubs:1075308
- Source identifiers:
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1075308
- Deposit date:
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2019-12-07
Terms of use
- Copyright date:
- 2019
- Notes:
- © 2019 Dahora, Jin, Spreng, Feely, Mathura, Seaton, Zhang, Hill, Jones, Alam, Dennison, Pollard and Tomaras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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