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Artesunate-mefloquine versus chloroquine for treatment of uncomplicated Plasmodium knowlesi malaria in Malaysia (ACT KNOW): An open-label, randomised controlled trial

Abstract:

Background: The zoonotic parasite Plasmodium knowlesi has become the most common cause of human malaria in Malaysia and is present throughout much of southeast Asia. No randomised controlled trials have been done to identify the optimum treatment for this emerging infection. We aimed to compare artesunate-mefloquine with chloroquine to define the optimum treatment for uncomplicated P knowlesi malaria in adults and children. Methods: We did this open-label, randomised controlled trial at three...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


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Malaysian Ministry of Health More from this funder
Australian National Health More from this funder
Medical Research Council More from this funder
Asia Pacific Malaria Elimination Network More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Volume:
16
Issue:
2
Pages:
180–188
Publication date:
2015-01-01
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
URN:
uuid:d6d93827-b29a-4d6c-9a93-2e719b3be566
Source identifiers:
579326
Local pid:
pubs:579326

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