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The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.

Abstract:

It is currently unclear whether the GluN2 subtype influences NMDA receptor (NMDAR) excitotoxicity. We report that the toxicity of NMDAR-mediated Ca(2+) influx is differentially controlled by the cytoplasmic C-terminal domains of GluN2B (CTD(2B)) and GluN2A (CTD(2A)). Studying the effects of acute expression of GluN2A/2B-based chimeric subunits with reciprocal exchanges of their CTDs revealed that CTD(2B) enhances NMDAR toxicity, compared to CTD(2A). Furthermore, the vulnerability of forebrain...

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Authors


Martel, MA More by this author
Fowler, JH More by this author
McMahon, A More by this author
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Journal:
Neuron
Volume:
74
Issue:
3
Pages:
543-556
Publication date:
2012-05-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:d6d4d53e-648b-449d-bbad-afea30296dd5
Source identifiers:
428087
Local pid:
pubs:428087

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