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Combination of 13-Cis retinoic acid and lovastatin: marked antitumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice.

Abstract:

Currently, there are no reliably effective therapeutic options for metastatic pheochromocytoma (PCC) and paraganglioma. Moreover, there are no therapies that may prevent the onset or progression of tumors in patients with succinate dehydrogenase type B mutations, which are associated with very aggressive tumors. Therefore, we tested the approved and well-tolerated drugs lovastatin and 13-cis-retinoic acid (13cRA) in vitro in an aggressive PCC mouse cell line, mouse tumor tissue-derived (MTT) ...

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Publication status:
Published

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Publisher copy:
10.1210/en.2014-1027

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Publisher:
Endocrine Society
Journal:
Endocrinology
Volume:
155
Issue:
7
Pages:
2377-2390
Publication date:
2014-07-05
DOI:
EISSN:
1945-7170
ISSN:
0013-7227
URN:
uuid:d6c913c8-0a62-454e-9bb7-8d8eca2d0cd1
Source identifiers:
471158
Local pid:
pubs:471158

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