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Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

Abstract:

Fronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Based on the overall expression in human fronto-striatal circuitry, we tested the effects of a cAMP selective phosphodiesterase 4 (PDE4) inhibitor on the tri-phasic response in the dorsomedial substant...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00429-017-1518-8

Authors


Heckman, PRA More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
ORCID:
0000-0002-5968-3534
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Oxford college:
University
ORCID:
0000-0001-7434-9713
Prickaerts, J More by this author
Blokland, A More by this author
Human Enhancement and Learning (HEaL) initiative of Maastricht University More from this funder
Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Brain Structure and Function Journal website
Volume:
223
Issue:
2
Pages:
739-748
Publication date:
2017-09-18
Acceptance date:
2017-09-12
DOI:
EISSN:
1863-2661
ISSN:
1863-2653
Pubs id:
pubs:730185
URN:
uri:d6c8e5f1-e762-4731-9d24-0e90b28292d4
UUID:
uuid:d6c8e5f1-e762-4731-9d24-0e90b28292d4
Local pid:
pubs:730185

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