Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.

Journal article

Combinations are set to become the mainstay in treatment and prophylaxis of malaria due to Plasmodium falciparum. Various antimalarials have been implicated in cardiotoxicity via prolongation of the QTc interval. Atovaquone-proguanil is an effective and increasingly popular antimalarial choice when used alone or with artesunate in areas of drug resistance. We report the results of an investigation carried out on the Thai-Burmese border in 42 patients randomized to receive either atovaquone-pr...

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Authors: Gupta, R; Van Vugt, M; Paiphun, L; Slight, T; Looareesuwan, S

• Publication status: Published
• Journal: American journal of tropical medicine and hygiene
• Volume: 73
• Issue: 2
• Pages: 267-268
• Publication date: 2005-08-01
• EISSN: 1476-1645
• ISSN: 0002-9637
• Language: English
• Keywords: Adolescent; Proguanil; Humans; Myocardium; Treatment Outcome; Adult; Middle Aged; Animals; Sesquiterpenes; Female; Drug Therapy, Combination; Thailand; Male; Malaria, Falciparum; Electrocardiography; Child; Artemisinins; Myanmar; Antimalarials; Atovaquone; Heart Diseases; Naphthoquinones; Plasmodium falciparum; Long QT Syndrome