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Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

Abstract:

Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so that severe haemolysis can be avoided. The patterns of oxidative haemolysis have been well described in G6PD deficient hemizygous males and homozygous females; and haemolysis in the proportionally more numerous heterozygous females has been documented mainly following consumption of fava...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-018-2248-y

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
ORCID:
0000-0003-4550-0431
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Luzzatto, L More by this author
Wellcome Trust More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
17
Pages:
Article: 101
Publication date:
2018-03-02
Acceptance date:
2018-02-24
DOI:
EISSN:
1475-2875
ISSN:
1475-2875
Pubs id:
pubs:828068
URN:
uri:d6b8936a-e53b-41c3-9f34-1ae33c76ebf3
UUID:
uuid:d6b8936a-e53b-41c3-9f34-1ae33c76ebf3
Local pid:
pubs:828068

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