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Thesis

Lim-only domain proteins in developmental haematopoiesis

Abstract:

The production of adult blood initiates from the haematopoietic stem cell (HSC). This clinically important cell has the capacity to maintain all blood lineages throughout the lifetime of an organism. HSCs emerge de novo from the haemogenic endothelium in the ventral wall of the embryonic dorsal aorta, from where they go on to seed adult sites of haematopoiesis. We have shown that Lmo4a is required for the emergence of HSCs in the zebrafish, and go on to demonstrate that Lmo4a regulates exp...

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Institution:
University of Oxford
Research group:
The Patient Lab
Oxford college:
Wolfson College
Department:
Medical Sciences Division - Clinical Laboratory Sciences

Contributors

Role:
Supervisor
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Funding agency for:
Kapil Tuladhar
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:d6b73e89-7095-402f-9d9f-4d7837a4db00
Local pid:
ora:6943

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