- Abstract:
-
The production of adult blood initiates from the haematopoietic stem cell (HSC). This clinically important cell has the capacity to maintain all blood lineages throughout the lifetime of an organism. HSCs emerge de novo from the haemogenic endothelium in the ventral wall of the embryonic dorsal aorta, from where they go on to seed adult sites of haematopoiesis. We have shown that Lmo4a is required for the emergence of HSCs in the zebrafish, and go on to demonstrate that Lmo4a regulates exp...
Expand abstract - Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
- URN:
-
uuid:d6b73e89-7095-402f-9d9f-4d7837a4db00
- Local pid:
- ora:6943
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- Kapil Tuladhar
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available in ORA
Thesis
Lim-only domain proteins in developmental haematopoiesis
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