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Thesis

Investigating resistance mechanisms to ATR inhibitors

Abstract:

The kinase activity of Ataxia-Telangiectasia and Rad3 related (ATR) protein plays a key role in controlling the DNA damage response (DDR) by acting through downstream targets to stabilise DNA replication forks, induce a transient cell cycle arrest to facilitate the repair of DNA, and thereby prevent premature mitosis in cells with unrepaired or unreplicated DNA. ATR is activated when single stranded DNA arises, for example, from stalled DNA replication forks or during the intermediate step...

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Department:
University of Oxford, Oriel College, Marshall Scholar
Role:
Author

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Role:
Supervisor
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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