Expression of complexin I and II mRNAs and their regulation by antipsychotic drugs in the rat forebrain.

Journal article

Complexin (cx) I and II are homologous synaptic protein genes which are differentially expressed in mouse and human brain and differentially affected in schizophrenia. We characterized the distribution of cx I and II mRNAs in rat forebrain and examined whether their abundance, or the transcript of the synaptic marker synaptophysin, is affected by 14 days' administration of antipsychotic drugs (haloperidol, chlorpromazine, risperidone, olanzapine, or clozapine). Cx I mRNA predominated in media...

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Authors: Eastwood, S; Burnet, P; Harrison, P

• Publication status: Published
• Journal: Synapse (New York, N.Y.)
• Volume: 36
• Issue: 3
• Pages: 167-177
• Publication date: 2000-06-01
• DOI: 10.1002/(sici)1098-2396(20000601)36:3<167::aid-syn2>3.0.co;2-d
• EISSN: 1098-2396
• ISSN: 0887-4476
• Language: English
• Keywords: Animals; Rats, Sprague-Dawley; Rats; Prosencephalon; Tissue Distribution; Male; RNA, Messenger; Synaptophysin; Antipsychotic Agents; Nerve Tissue Proteins