Enantioselective synthesis of chiral building blocks with non-stabilized nucleophiles
This thesis describes the combination of non-stabilized nucleophiles and prochiral/racemic electrophiles in transition metal catalyzed asymmetric transformations. These enantioselective reactions have tremendous potential for the formation of chiral building blocks and new structural motifs that can be found in a variety of natural products and their derivatives.
The first part of the thesis focuses on the synthetic approach towards anti-cancer active diterpenoid structures. The two...Expand abstract
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- University of Oxford
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