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Identifying the components of acidosis in patients with severe plasmodium falciparum malaria Using metabolomics

Abstract:

Background

Acidosis in severe Plasmodium falciparum malaria is associated with high mortality yet the pathogenesis remains incompletely understood. The aim of this study was to determine the nature and source of metabolic acids contributing to acidosis in patients with severe falciparum malaria.

Methods

A prospective observational study was conducted to characterise circulating acids in adults with P. falciparum malaria (n=107) and healthy controls (n=45) from Ban...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/infdis/jiy727

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Tropical Medicine
Allman, EL More by this author
Kingston, HWF More by this author
Hossain, A More by this author
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
219
Issue:
11
Pages:
1766-1776
Publication date:
2018-12-19
Acceptance date:
2018-10-25
DOI:
EISSN:
1537-6613
ISSN:
1537-6613
Pubs id:
pubs:954679
URN:
uri:d695b5f6-50f4-40fc-8e83-29e86dbf2be6
UUID:
uuid:d695b5f6-50f4-40fc-8e83-29e86dbf2be6
Local pid:
pubs:954679

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