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Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.

Abstract:

Type I interferon (IFN) is crucial during infection through its antiviral properties and by coordinating the immunocompetent cells involved in antiviral or antibacterial immunity. Type I IFN (IFN-α and IFN-β) is produced after virus or bacteria recognition by cytosolic receptors or membrane-bound TLR receptors following the activation of the transcription factors IRF3 or IRF7. IFN-β production after fungal infection was recently reported, although the underlying mechanism remains controversia...

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Publication status:
Published

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Journal:
Immunity
Volume:
38
Issue:
6
Pages:
1176-1186
Publication date:
2013-06-05
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
URN:
uuid:d690fb43-1b89-4c11-8bb1-da214766448a
Source identifiers:
406429
Local pid:
pubs:406429

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