Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.

Journal article

The combination of chlorproguanil and dapsone is being considered as an alternative antimalarial to sulfadoxine-pyrimethamine in Africa, because of its greater efficacy against resistant parasites, and its shorter half-lives, which exert less selective pressure for the emergence of resistance. A triple artesunate-chlorproguanil-dapsone combination is under development. In a previous study of relatively low-dose chlorproguanil-dapsone in multidrug-resistant falciparum malaria in Thailand failu...

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Authors: Krudsood, S; Imwong, M; Wilairatana, P; Pukrittayakamee, S; Nonprasert, A

• Publication status: Published
• Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene
• Volume: 99
• Issue: 2
• Pages: 142-149
• Publication date: 2005-02-01
• DOI: 10.1016/j.trstmh.2004.07.001
• EISSN: 1878-3503
• ISSN: 0035-9203
• Language: English
• Keywords: Genotype; Prospective Studies; Treatment Outcome; Tetrahydrofolate Dehydrogenase; Drug Therapy, Combination; Artemisinins; Male; Dapsone; Antimalarials; Proguanil; Dihydropteroate Synthase; Humans; Female; Adolescent; Sesquiterpenes; Animals; Recurrence; Adult; Mutation; Plasmodium falciparum; Malaria, Falciparum; Middle Aged