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Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.

Abstract:

The expression of antibodies inside cells to ablate protein function has the potential for disease therapy and for target validation in functional genomics. However, due to inefficient expression or folding, only a few antibodies or antibody fragments, usually as single-chain Fv antibody fragments (scFv), bind their antigens in an intracellular environment. We have established a genetic-selection technology (intracellular antibody capture, IAC) to facilitate the isolation of functional intrac...

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Publisher copy:
10.1006/jmbi.2002.5403

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Journal:
Journal of molecular biology
Volume:
317
Issue:
1
Pages:
85-94
Publication date:
2002-03-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:d67caaa3-9d97-4a5d-ad37-2010f79fd285
Source identifiers:
324291
Local pid:
pubs:324291

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