- Abstract:
-
The expression of antibodies inside cells to ablate protein function has the potential for disease therapy and for target validation in functional genomics. However, due to inefficient expression or folding, only a few antibodies or antibody fragments, usually as single-chain Fv antibody fragments (scFv), bind their antigens in an intracellular environment. We have established a genetic-selection technology (intracellular antibody capture, IAC) to facilitate the isolation of functional intrac...
Expand abstract - Publisher copy:
- 10.1006/jmbi.2002.5403
-
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- Journal:
- Journal of molecular biology
- Volume:
- 317
- Issue:
- 1
- Pages:
- 85-94
- Publication date:
- 2002-03-05
- DOI:
- EISSN:
-
1089-8638
- ISSN:
-
0022-2836
- URN:
-
uuid:d67caaa3-9d97-4a5d-ad37-2010f79fd285
- Source identifiers:
-
324291
- Local pid:
- pubs:324291
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein.
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