- Abstract:
-
Various mechanisms are used by single-stranded RNA viruses to initiate and control their replication via the synthesis of replicative intermediates. In general, the same virus-encoded polymerase is responsible for both genome and antigenome strand synthesis from two different, although related promoters. Here we aimed to elucidate the mechanism of initiation of replication by influenza virus RNA polymerase and establish whether initiation of cRNA and viral RNA (vRNA) differed. To do this, two...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/jvi.80.5.2337-2348.2006
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- Journal:
- Journal of virology
- Volume:
- 80
- Issue:
- 5
- Pages:
- 2337-2348
- Publication date:
- 2006-03-05
- DOI:
- EISSN:
-
1098-5514
- ISSN:
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0022-538X
- URN:
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uuid:d674d689-1475-4fa4-8a8f-ffdcae2b5b33
- Source identifiers:
-
27592
- Local pid:
- pubs:27592
- Copyright date:
- 2006
Journal article
Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication.
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