In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.

Journal article

The LKB1/STK11 serine/threonine kinase is mutated in Peutz-Jeghers' syndrome and acts as a tumour suppressor. Using northern blotting and RT-PCR, LKB1 has been reported to be expressed widely in human adult tissues, although in Xenopus the expression of its homologue, XEEK1, is apparently restricted to early embryogenesis. In situ hybridization has been used to detect and localize LKB1 mRNA in a variety of adult and fetal tissues and tumours. The results show that LKB1 expression is widesprea...

Expand abstract

Authors: Rowan, A; Churchman, M; Jefferey, R; Hanby, A; Poulsom, R

• Publication status: Published
• Journal: Journal of pathology
• Volume: 192
• Issue: 2
• Pages: 203-206
• Publication date: 2000-10-01
• DOI: 10.1002/1096-9896(2000)9999:9999<::aid-path686>3.3.co;2-a
• EISSN: 1096-9896
• ISSN: 0022-3417
• Language: English
• Keywords: RNA, Messenger; Male; Gene Expression Regulation, Enzymologic; Humans; Female; Case-Control Studies; Epithelium; In Situ Hybridization; Protein-Serine-Threonine Kinases; Adult; Cell Division; Fetus; Seminiferous Tubules; Peutz-Jeghers Syndrome; Neoplasms