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Journal article

Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.

Abstract:

17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the conversion of 17beta-OH (-hydroxy)/17-oxo groups of steroids, and are essential in mammalian hormone physiology. At present, eleven 17beta-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17beta-HSD type 10 (17beta-HSD10) from humans and Drosophila, the latter known to be essential in development. In addition to the known hydroxyacyl-CoA dehydrogenase, and ...

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Publication status:
Published

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Publisher copy:
10.1042/bj20030877

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Journal:
The Biochemical journal
Volume:
376
Issue:
Pt 1
Pages:
49-60
Publication date:
2003-11-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:d65778ee-1ef9-4b0a-a885-a684b8d76ada
Source identifiers:
108489
Local pid:
pubs:108489

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