Journal article
Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.
- Abstract:
-
17beta-hydroxysteroid dehydrogenases (17beta-HSDs) catalyse the conversion of 17beta-OH (-hydroxy)/17-oxo groups of steroids, and are essential in mammalian hormone physiology. At present, eleven 17beta-HSD isoforms have been defined in mammals, with different tissue-expression and substrate-conversion patterns. We analysed 17beta-HSD type 10 (17beta-HSD10) from humans and Drosophila, the latter known to be essential in development. In addition to the known hydroxyacyl-CoA dehydrogenase, and ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1042/bj20030877
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Bibliographic Details
- Journal:
- Biochemical journal
- Volume:
- 376
- Issue:
- Pt 1
- Pages:
- 49-60
- Publication date:
- 2003-11-01
- DOI:
- EISSN:
-
1470-8728
- ISSN:
-
0264-6021
- Source identifiers:
-
108489
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:108489
- UUID:
-
uuid:d65778ee-1ef9-4b0a-a885-a684b8d76ada
- Local pid:
- pubs:108489
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2003
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