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Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in type-I interferon response

Abstract:

The pattern recognition receptor RIG-I is critical for Type-I interferon production. However, the global regulation of RIG-I signaling is only partially understood. Using a human genome-wide RNAi-screen, we identified 226 novel regulatory proteins of RIG-I mediated interferon-β production. Furthermore, the screen identified a metabolic pathway that synthesizes the inositol pyrophosphate 1-IP7 as a previously unrecognized positive regulator of interferon production. Detailed genetic and bioche...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1003981

Authors


Pulloor, NK More by this author
Kostic, AD More by this author
Weaver, JD More by this author
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Grant:
HHSN266200700010C
Publisher:
PLoS Publisher's website
Journal:
PLoS Pathogens Journal website
Volume:
10
Issue:
2
Pages:
e1003981
Publication date:
2014-02-27
Acceptance date:
2014-01-22
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Pubs id:
pubs:640291
URN:
uri:d650fcb1-4ebf-416d-ae76-ab86373634ae
UUID:
d650fcb1-4ebf-416d-ae76-ab86373634ae
Local pid:
pubs:640291

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