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Regulation of antigen-expressing dendritic cells by double negative regulatory T cells.

Abstract:

TCRαβ(+) CD3(+) CD4(-) CD8(-) NK1.1(-) double negative (DN) Tregs comprise 1-3% of peripheral T lymphocytes in mice and humans. It has been demonstrated that DN Tregs can suppress allo-, xeno- and auto-immune responses in an Ag-specific fashion. However, the mechanisms by which DN Tregs regulate immune responses remain elusive. Whether DN Tregs can regulate DCs has not been investigated previously. In this study, we demonstrate that DN Tregs express a high level of CTLA4 and are able to down...

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Publisher copy:
10.1002/eji.201141428

Authors


McIntyre, MS More by this author
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Journal:
European journal of immunology
Volume:
41
Issue:
9
Pages:
2699-2708
Publication date:
2011-09-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:d64c5e48-f27d-41ff-aab2-561ffbce740b
Source identifiers:
400591
Local pid:
pubs:400591

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