Journal article icon

Journal article

The actin cytoskeleton modulates the activation of invariant NKT cells by segregating CD1d nanoclusters on antigen presenting cells

Abstract:

Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipid antigens presented in the context of CD1d molecules. The ability of iNKT cells to recognize endogenous antigens represents a distinct immune recognition strategy, which underscores the constitutive memory phenotype of iNKT cells and their activation during inflammatory conditions. However, the mechanisms regulating such “tonic” activation of iNKT cells remain unclear. Here, we show that the spatiotemporal distrib...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1073/pnas.1514530113

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More from this funder
Name:
Austrian Science Fund
Funding agency for:
Aichinger, M
Grant:
FWF:J3045- B11
More from this funder
Name:
Cancer Research UK
Grant:
C399/A2291
More from this funder
Name:
LaserLab Europe
Grant:
GA 284464
More from this funder
Name:
European Council
Grant:
FP7-NANO-VISTA GA 288263
More from this funder
Name:
Human Frontiers Science Program
Grant:
GA RGP0027/2012
Keywords:
Pubs id:
pubs:597636
UUID:
uuid:d6488eb1-1923-49e2-8757-94e9251f6f21
Local pid:
pubs:597636
Source identifiers:
597636
Deposit date:
2016-01-26

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP