Treatment planning for a synchrotron-based radiotherapy modality.

Journal article

Contrast enhanced radiotherapy (CERT) achieves biologically localised dose enhancement through the preferential uptake of high-Z media by the tumour cells. A treatment planning software originally developed for boron neutron capture therapy (BNCT) has been developed to evaluate treatment plans for CERT. A realistic test case of a brain tumour based on actual CT scans was used to calculate dose distributions with and without the presence of an iodinated contrast medium. An enhancement of dose was observed at all depths with the introduction of iodine and the corresponding dose enhancement factors were calculated for various concentrations.

Authors: Manolopoulos, S; Wojnecki, C; Green, S; Hugtenburg, R; Jones, B

• Publication status: Published
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
• Volume: 67
• Issue: 3
• Pages: 492-494
• Publication date: 2009-03-01
• DOI: 10.1016/j.apradiso.2008.08.005
• EISSN: 1872-9800
• ISSN: 0969-8043
• Language: English
• Keywords: Brain Neoplasms; Humans; Contrast Media; Boron Neutron Capture Therapy; Software; Synchrotrons; Radiotherapy Dosage; Tomography; Iodine