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Journal article

Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging.

Abstract:

Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a "hit region" of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both the number of underlying true signals and their identities ambiguous. Simultaneous modeling of multiple loci should help. However, it is typically applied ad hoc: conditioning on the top SNPs, with l...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.21639

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Genetic epidemiology
Volume:
36
Issue:
5
Pages:
451-462
Publication date:
2012-07-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Source identifiers:
342089
Language:
English
Keywords:
Pubs id:
pubs:342089
UUID:
uuid:d63f4ab9-b1a2-466c-a03a-1c580a6c8110
Local pid:
pubs:342089
Deposit date:
2013-11-17

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