Journal article icon

Journal article

Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging.

Abstract:

Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a "hit region" of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both the number of underlying true signals and their identities ambiguous. Simultaneous modeling of multiple loci should help. However, it is typically applied ad hoc: conditioning on the top SNPs, with l...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/gepi.21639

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
Journal:
Genetic epidemiology
Volume:
36
Issue:
5
Pages:
451-462
Publication date:
2012-07-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:d63f4ab9-b1a2-466c-a03a-1c580a6c8110
Source identifiers:
342089
Local pid:
pubs:342089

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP