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Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation.

Abstract:

Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix and nonmatrix proteins, particularly basement membrane constituents. Thus, any naturally occurring genetic variants that directly affect gene expression and/or protein function would be expected to impact on progression of pathological processes involving tissue remodeling. We scanned a 2-kilobase pair promoter region and all 13 exons of the human MMP-2 gene, from a panel of 32 individuals, and we identif...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m010242200

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of biological chemistry
Volume:
276
Issue:
10
Pages:
7549-7558
Publication date:
2001-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
12331

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