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Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.

Abstract:

Virus-specific CD8+ T cell responses play an important role in the natural course of infection; however, the impact of certain CD8+ T cell responses in determining clinical outcome has not been fully defined. A well-defined cohort of women inoculated with HCV from a single source showed that HLA-B27 has a strong association with spontaneous clearance. The immunological basis for this association is unknown. However, the finding is especially significant because HLA-B27 has also been shown to ...

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Publication status:
Published

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Publisher copy:
10.1002/hep.21049

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Journal:
Hepatology (Baltimore, Md.)
Volume:
43
Issue:
3
Pages:
563-572
Publication date:
2006-03-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:d63b5fdc-ac2b-4ba8-b45d-399bdb139e4d
Source identifiers:
23509
Local pid:
pubs:23509

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