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Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture.

Abstract:

Remodeling imbalance in the elderly femoral neck can result in thin cortices and porosity predisposing to hip fracture. Hip osteoarthritis protects against intracapsular hip fracture. By secreting sclerostin, osteocytes may inhibit Wnt signaling and reduce bone formation by osteoblasts. We hypothesised that differences in osteocytic sclerostin expression might account for differences in osteonal bone-formation activity between controls and subjects with hip fracture or hip osteoarthritis. Usi...

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Publication status:
Published

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Publisher copy:
10.1002/jbmr.70

Authors


van Bezooijen, R More by this author
Caballero-Alías, AM More by this author
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Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Volume:
25
Issue:
8
Pages:
1867-1876
Publication date:
2010-08-05
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
URN:
uuid:d63ad046-7f19-44ff-8704-8cb9842f97df
Source identifiers:
473641
Local pid:
pubs:473641

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