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Journal article

DNA mismatch repair genes and colorectal cancer.

Abstract:

Positional cloning and linkage analysis have shown that inactivation of one of the mismatch repair genes (hMLH1, hMSH2, hPMS1, hPMS2, GTBP/hMSH6) is responsible for the microsatellite instability or replication error (RER+) seen in more than 90% of hereditary nonpolyposis colorectal cancers (HNPCC) and 15% of sporadic RER+ colorectal cancers. In HNPCC, a germline mutation (usually in hMLH1 or hMSH2) is accompanied by one further event (usually allelic loss) to inactivate a mismatch repair gen...

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Publication status:
Published

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Publisher copy:
10.1136/gut.47.1.148

Authors


Wheeler, JM More by this author
Bodmer, WF More by this author
Mortensen, NJ More by this author
Journal:
Gut
Volume:
47
Issue:
1
Pages:
148-153
Publication date:
2000-07-05
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:d63175f4-dafb-4435-8ad0-4444843755af
Source identifiers:
178000
Local pid:
pubs:178000

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