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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.

Abstract:

BACKGROUND AND AIMS: Genetic variation in NOD2 has been associated with susceptibility to Crohn's disease (CD) and specifically with ileal involvement. The reason for the unique association of NOD2 mutations with ileal disease is unclear. To identify a possible link, we tested expression of NOD2 in intestinal tissue of CD patients and controls. PATIENTS AND METHODS: Fifty five specimens of ileum or colon from 21 CD patients, seven ulcerative colitis (UC) patients, and five controls with patho...

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Publication status:
Published

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Publisher copy:
10.1136/gut.52.11.1591

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Journal:
Gut More from this journal
Volume:
52
Issue:
11
Pages:
1591-1597
Publication date:
2003-11-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749

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