Journal article icon

Journal article

A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

Abstract:

We describe a novel type of human thrombocytopenia characterized by the appearance of giant platelets and variable neutropenia. Searching for the molecular defect, we found that neutrophils had strongly reduced sialyl-Lewis X and increased Lewis X surface expression, pointing to a deficiency in sialylation. We show that the glycosylation defect is restricted to α2,3-sialylation and can be detected in platelets, neutrophils, and monocytes. Platelets exhibited a distorted structure of the open ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Journal:
American journal of pathology More from this journal
Volume:
179
Issue:
4
Pages:
1969-1977
Publication date:
2011-10-01
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
Language:
English
Keywords:
Pubs id:
pubs:172083
UUID:
uuid:d61a49b9-9a41-4023-9dce-b9f3362556dc
Local pid:
pubs:172083
Source identifiers:
172083
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP