Journal article
Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidaemia
- Abstract:
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Diabetes is a well-established risk factor for heart disease leading to impaired cardiac function and a metabolic switch towards fatty acid usage. Here, we investigated if hyperglycaemia/hypoinsulinaemia in the absence of dyslipidaemia is sufficient to drive these changes, and if they can be reversed by restoring euglycaemia. Using the βV59M mouse model, in which diabetes can be rapidly induced and reversed, we show that stroke volume and cardiac output were reduced within two weeks of diabet...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
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- Files:
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(pdf, 11.0MB)
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- Publisher copy:
- 10.2337/db17-1195
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Authors
Funding
Bibliographic Details
- Publisher:
- American Diabetes Association Publisher's website
- Journal:
- Diabetes Journal website
- Volume:
- 67
- Issue:
- 6
- Pages:
- 1057-1067
- Publication date:
- 2018-04-02
- Acceptance date:
- 2018-03-11
- DOI:
- EISSN:
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1939-327X
- ISSN:
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0012-1797
- Pubs id:
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pubs:833971
- URN:
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uri:d61a41e2-6de2-4109-9e52-0cd0da31381a
- UUID:
-
uuid:d61a41e2-6de2-4109-9e52-0cd0da31381a
- Local pid:
- pubs:833971
Item Description
- Language:
- English
Terms of use
- Copyright holder:
- American Diabetes Association
- Copyright date:
- 2018
- Notes:
-
Copyright © 2018 by the American Diabetes Association. This is the accepted manuscript version of the article. The final version is available online from American Diabetes Association at: https://doi.org/10.2337/db17-1195
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