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Cardiac dysfunction and metabolic inflexibility in a mouse model of diabetes without dyslipidaemia

Abstract:

Diabetes is a well-established risk factor for heart disease leading to impaired cardiac function and a metabolic switch towards fatty acid usage. Here, we investigated if hyperglycaemia/hypoinsulinaemia in the absence of dyslipidaemia is sufficient to drive these changes, and if they can be reversed by restoring euglycaemia. Using the βV59M mouse model, in which diabetes can be rapidly induced and reversed, we show that stroke volume and cardiac output were reduced within two weeks of diabet...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.2337/db17-1195

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
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Funding agency for:
Fischer, R
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Funding agency for:
Ashcroft, FM
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Funding agency for:
Ashcroft, FM
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Grant:
ERC Advanced grant 322620
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Publisher:
American Diabetes Association Publisher's website
Journal:
Diabetes Journal website
Volume:
67
Issue:
6
Pages:
1057-1067
Publication date:
2018-04-02
Acceptance date:
2018-03-11
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pubs id:
pubs:833971
URN:
uri:d61a41e2-6de2-4109-9e52-0cd0da31381a
UUID:
uuid:d61a41e2-6de2-4109-9e52-0cd0da31381a
Local pid:
pubs:833971
Language:
English

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