Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy.

Journal article

OBJECTIVE: To investigate the potential role of IkappaB kinase 1 (IKK-1) and IKK-2 in the regulation of nuclear factor kappaB (NF-kappaB) activation and the expression of tumor necrosis factor alpha (TNFalpha), as well as interleukin-1beta (IL-1beta), IL-6, IL-8, vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMPs), in rheumatoid arthritis (RA). METHODS: Recombinant adenoviruses expressing beta-galactosidase, dominant-negative IKK-1 and IKK-2, or IkappaBalpha were ...

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Authors: Andreakos, E; Smith, C; Kiriakidis, S; Monaco, C; de Martin, R

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 48
• Issue: 7
• Pages: 1901-1912
• Publication date: 2003-07-01
• DOI: 10.1002/art.11044
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Monocytes; Matrix Metalloproteinases; Matrix Metalloproteinase 2; NF-kappa B; Tumor Necrosis Factor-alpha; Interleukin-6; Humans; Endothelium, Vascular; Endothelial Growth Factors; Skin; Protein-Serine-Threonine Kinases; Matrix Metalloproteinase 1; Cells, Cultured; Cytokines; Intercellular Signaling Peptides and Proteins; Interleukin-1; Umbilical Veins; Arthritis, Rheumatoid; Fibroblasts; Matrix Metalloproteinase 13; Lipopolysaccharides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Macrophages; Collagenases; Interleukin-8; Matrix Metalloproteinase 3; I-kappa B Kinase; Synovial Membrane; Lymphokines